The isochore organization of the human genome and its evolutionary history--a review.

@article{Bernardi1993TheIO,
  title={The isochore organization of the human genome and its evolutionary history--a review.},
  author={Giorgio Bernardi},
  journal={Gene},
  year={1993},
  volume={135 1-2},
  pages={57-66}
}
This review will first present some properties (including compositional pattern, correlations between isochores and chromosomal bands, and gene distribution) of the human genome, the most extensively studied among vertebrate genomes. It will then explain how these properties came about during the evolution of the vertebrates. 

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