The ischemia-selective KATP channel antagonist, 5-hydroxydecanoate, blocks ischemic preconditioning in the rat heart.

@article{Schultz1997TheIK,
  title={The ischemia-selective KATP channel antagonist, 5-hydroxydecanoate, blocks ischemic preconditioning in the rat heart.},
  author={Jo El J. Schultz and Yong Zhen Qian and Garrett Gross and Rakesh C. Kukreja},
  journal={Journal of molecular and cellular cardiology},
  year={1997},
  volume={29 3},
  pages={
          1055-60
        }
}
Although the KATP channel has been demonstrated to be involved in ischemic preconditioning (IPC) in most species, controversy still exists as to the role of this channel as a mediator of PC in the rat heart. Previously, the authors' laboratories have shown that glibenclamide blocks IPC in the intact rat heart, in a time-dependent manner; however, since glibenclamide has been shown to have non-selective effects unrelated to KATP channel blockade, a structurally dissimilar and ischemia-selective… CONTINUE READING

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