The irradiation effects on the cytoskeletons of C3H/He mouse mammary tumor cells and vascular basement membrane in relation to vascular invasion: a model of intraoperative radiotherapy.

@article{Kobayashi1988TheIE,
  title={The irradiation effects on the cytoskeletons of C3H/He mouse mammary tumor cells and vascular basement membrane in relation to vascular invasion: a model of intraoperative radiotherapy.},
  author={Motoko Kobayashi},
  journal={The Tohoku journal of experimental medicine},
  year={1988},
  volume={154 1},
  pages={71-89}
}
We investigated the short-term effects of a single high-dose radiation upon transplanted MM46 tumor cells in mice by means of immunohistochemistry and electron microscopy. The irradiation induced: 1) giant cell formation from the 3rd day, 2) arrest of tumor cell mitosis in prophase and metaphase due to the disorganization of the mitotic spindles, 3) changes in immunoreactivity of laminin and cytoskeletons, and 4) multilayering of the vascular basal lamina and perivascular fibrosis. The above… CONTINUE READING