The iron-sulphur protein Ind1 is required for effective complex I assembly.

@article{Bych2008TheIP,
  title={The iron-sulphur protein Ind1 is required for effective complex I assembly.},
  author={Katrine Bych and Stefan Kerscher and Daili J Aguilar Netz and Antonio J. Pierik and Klaus Zwicker and Martijn A. Huynen and Roland Lill and Ulrich Brandt and Janneke Balk},
  journal={The EMBO journal},
  year={2008},
  volume={27 12},
  pages={1736-46}
}
NADH:ubiquinone oxidoreductase (complex I) of the mitochondrial inner membrane is a multi-subunit protein complex containing eight iron-sulphur (Fe-S) clusters. Little is known about the assembly of complex I and its Fe-S clusters. Here, we report the identification of a mitochondrial protein with a nucleotide-binding domain, named Ind1, that is required specifically for the effective assembly of complex I. Deletion of the IND1 open reading frame in the yeast Yarrowia lipolytica carrying an… CONTINUE READING

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