The ionic mechanisms underlying N-methyl-d-aspartate receptor-induced, tetrodotoxin-resistant membrane potential oscillations in lamprey neurons active during locomotion

@article{Grillner1985TheIM,
  title={The ionic mechanisms underlying N-methyl-d-aspartate receptor-induced, tetrodotoxin-resistant membrane potential oscillations in lamprey neurons active during locomotion},
  author={Sten Grillner and Peter Wall{\'e}n},
  journal={Neuroscience Letters},
  year={1985},
  volume={60},
  pages={289-294}
}
Activation of N-methyl-D-aspartate (NMDA) receptors can induce tetrodotoxin (TTX)-resistant membrane potential oscillations as well as fictive locomotion in the in vitro preparation of the lamprey spinal cord. The ionic basis of these oscillations were investigated in the presence of N-methyl-D,L-aspartate and TTX. Addition of blocking agents (2-amino-5-phosphonovalerate and tetraethylammonium (TEA)) and selective removal or substitution of certain ions (Mg2+, Ca2+, Na+, Ba2+) were used in the… CONTINUE READING

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