The ion channel behavior of the nuclear pore complex

  title={The ion channel behavior of the nuclear pore complex},
  author={Jos{\'e} Omar Bustamante and John A Hanover and Andrejs Liepins},
  journal={The Journal of Membrane Biology},
Macromolecule-conducting pores have been recently recognized as a distinct class of ion channels. The poor role of macromolecules as electrical charge carriers can be used to detect their movement along electrolyte-filled pores. Because of their negligible contribution to electrical ion currents, translocating macromolecules reduce the net conductivity of the medium inside the pore, thus decreasing the measured pore ion conductance. In the extreme case, a large translocating macromolecule can… CONTINUE READING


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