The inward rectifier current (IK1) controls cardiac excitability and is involved in arrhythmogenesis.

@article{Dhamoon2005TheIR,
  title={The inward rectifier current (IK1) controls cardiac excitability and is involved in arrhythmogenesis.},
  author={Amit S. Dhamoon and Jos{\'e} Jalife},
  journal={Heart rhythm},
  year={2005},
  volume={2 3},
  pages={316-24}
}
The cardiac inwardly rectifying potassium current (I(K1)) stabilizes the resting membrane potential and is responsible for shaping the initial depolarization and final repolarization of the action potential. The inwardly rectifying potassium channel (Kir2.x) subfamily members primarily mediate cardiac I(K1), but other inward rectifiers, including the acetylcholine-sensitive (Kir3.x) and ATP-sensitive (Kir6.x) inward rectifiers, also may modulate cardiac excitability. Studies suggest I(K1) plays… CONTINUE READING
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