The involvement of the sigma-1 receptor in neurodegeneration and neurorestoration.

  title={The involvement of the sigma-1 receptor in neurodegeneration and neurorestoration.},
  author={Karsten Ruscher and Tadeusz Wieloch},
  journal={Journal of pharmacological sciences},
  volume={127 1},
The sigma-1 receptor (Sig-1R) is a single 25 kD polypeptide and a chaperone protein immersed in lipid rafts of the endoplasmic reticulum (ER) where it interacts with mitochondria at the mitochondria-associated ER membrane domain (MAM). Upon activation, the Sig-1R binds to the inositol trisphosphate receptor (IP3R), and modulates cellular calcium (Ca(2+)) homeostasis. Also, the activated Sig-1R modulates plasma membrane receptor and ion channel functions, and may regulate cellular excitability… CONTINUE READING
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