The involvement of the cerebellum in amyotrophic lateral sclerosis.

  title={The involvement of the cerebellum in amyotrophic lateral sclerosis.},
  author={Tino Prell and Julian Grosskreutz},
  journal={Amyotrophic lateral sclerosis & frontotemporal degeneration},
  volume={14 7-8},
Amyotrophic lateral sclerosis is a multisystemic neurodegenerative disease in which degenerative processes are not exclusively restricted to the upper and lower motor neurons. Herein, imaging and neuropathological evidence for involvement of the cerebellum, which to date is not thought to be involved in ALS, is reviewed. Evidence for involvement of the cerebellum in ALS comes from several neuropathological studies. Especially ubiquitinated forms of TDP-43 and ubiquitinated p62-positive… CONTINUE READING
Highly Cited
This paper has 39 citations. REVIEW CITATIONS


Publications citing this paper.
Showing 1-10 of 25 extracted citations


Publications referenced by this paper.
Showing 1-10 of 75 references

ebellar neural circuits

H Takahashi, K Oyanagi, F Ikuta, M Tanaka, T Yuasa
Dev Growth Differ • 2012
View 3 Excerpts
Highly Influenced

TDP-43 negative, neuronal cytoplasmic and intranuclear inclusions in the cerebellum and hippoc- ampus defi ne the pathology of C9orf72-linked FTLD and MND/ALS

et al . p62-positive
Acta Neuropathol • 2011
View 9 Excerpts
Highly Influenced

eration with ubiquitinated tau-negative inclusions and addi- tional alpha-synuclein pathology but also unusual cerebellar ubiquitinated p62-positive, TDP-43-negative inclusions

C Troakes, S Maekawa, L Wijesekera, B Rogelj, L Siklos
Neuropathology • 2009
View 6 Excerpts
Highly Influenced

antibodies for neuropathological diagnosis

EH Bigio, S Weintraub, R Rademakers, M Baker
Neuropathol Appl Neurobiol • 2008
View 4 Excerpts
Highly Influenced

How do C 9 orf 72 repeat expansions cause amyotrophic lateral sclerosis and frontotemporal dementia : can we learn from other non - coding repeat expansion disorders ?

M vanBlitterswijk, M DeJesus-Hernandez, R Rademakers
Curr Opin Neurol • 2012