The involvement of the Saccharomyces cerevisiae multidrug resistance transporters Pdr5p and Snq2p in cation resistance.

@article{Miyahara1996TheIO,
  title={The involvement of the Saccharomyces cerevisiae multidrug resistance transporters Pdr5p and Snq2p in cation resistance.},
  author={Kohji Miyahara and Masaki Mizunuma and Daniel Ono Hirata and Eiko Tsuchiya and Tokichi Miyakawa},
  journal={FEBS letters},
  year={1996},
  volume={399 3},
  pages={
          317-20
        }
}
The ATP-binding cassette superfamily proteins Pdr5p and Snq2p of Saccharomyces cerevisiae are implicated in multidrug resistance. Here, we show that these transporters are also involved in cation resistance. Null mutants of PDR5 and SNQ2 genes exhibit increased sensitivity to NaCl, LiCl and MnCl2. The mutant cells grown in the presence of high concentrations of these metal salts contain higher levels of the metals than wild-type cells. The expression of PDR5 and SNQ2 is induced by the metal… CONTINUE READING
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