The involvement of the GPR39-Zn(2+)-sensing receptor in the pathophysiology of depression. Studies in rodent models and suicide victims.

@article{Myniec2014TheIO,
  title={The involvement of the GPR39-Zn(2+)-sensing receptor in the pathophysiology of depression. Studies in rodent models and suicide victims.},
  author={Katarzyna Młyniec and Urszula Doboszewska and Bernadeta Szewczyk and Magdalena Sowa-Ku{\'c}ma and Paulina Misztak and Wojciech Piekoszewski and Franciszek Trela and Beata Ostachowicz and Gabriel Nowak},
  journal={Neuropharmacology},
  year={2014},
  volume={79},
  pages={290-7}
}
Zinc is one of the most important trace elements in our body. Patients suffering from depression show lower serum zinc levels compared to healthy controls. Zincs antagonism to the glutamatergic system seems to be responsible for mood recovery. Recent years have shown that zinc may regulate neurotransmission via the metabotropic GPR39 receptor. Activation of the GPR39-Zn(2+)-sensing receptor (GPR39) triggers diverse neuronal pathways leading to a cAMP-responsive element binding the protein (CREB… CONTINUE READING

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Zinc de fi ciency induces behavioral alterations in the tail suspension test in mice . Effect of antidepressants

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