The involvement of the Ca-dependent K channel and of the KCl co-transport in sickle cell dehydration during cyclic deoxygenation.

@article{Apovo1994TheIO,
  title={The involvement of the Ca-dependent K channel and of the KCl co-transport in sickle cell dehydration during cyclic deoxygenation.},
  author={M Apovo and Yves Beuzard and Fr{\'e}d{\'e}ric Galact{\'e}ros and Dora Bachir and Françoise Giraud},
  journal={Biochimica et biophysica acta},
  year={1994},
  volume={1225 3},
  pages={255-8}
}
We have investigated the mechanisms involved in sickle cell dehydration upon continuous or cyclic deoxygenation: the Ca(2+)-activated K+ channel and the KCl co-transport system. Short-term continuous deoxygenation (1 h) of sickle cells in a Ca(2+)-containing medium promoted a stimulation of the efflux of K+ and cell dehydration. This latter was reduced by the replacement of Ca2+ in the medium by EGTA, but not by addition of [(dihydro-indenyl) oxy] alkanoic acid (DIOA), an inhibitor of the KCl… CONTINUE READING

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