The involvement of pertussis toxin‐sensitive G proteins in the post receptor mechanism of central I1‐imidazoline receptors

  title={The involvement of pertussis toxin‐sensitive G proteins in the post receptor mechanism of central I1‐imidazoline receptors},
  author={K. Takada and Y. Hayashi and T. Kamibayashi and T. Mammoto and A. Yamatodani and S. Kitamura and I. Yoshiya},
  journal={British Journal of Pharmacology},
To elucidate the possible involvement of pertussis toxin (PTX)‐sensitive G proteins in the post receptor mechanism of α2‐adrenoceptors and imidazoline receptors, we examined the effect of pretreatment of the central nervous system with PTX on the antidysrhythmic effect of dexmedetomidine, a selective α2‐adrenoceptor agonist, and rilmenidine, a selective I1‐imidazoline receptor agonist on halothane‐adrenaline dysrhythmias in rats. Dexmedetomidine (0, 1.0, 2.0, 5.0 μg kg−1 min−1, i.v.) and… Expand
The Effect of Imidazoline Receptors and α2‐adrenoceptors on the Anesthetic Requirement (MAC) for Halothane in Rats
The present data indicate that the anesthetic sparing action of dexmedetomidine is most likely mediated through alpha2 ‐adrenoceptors, and the stimulation of imidazoline receptors exerts little effect on theAnesthetic requirement for halothane. Expand
Involvement of phosphatidylcholine‐selective phospholipase C in activation of mitogen‐activated protein kinase pathways in imidazoline receptor antisera‐selected protein
  • Fei Li, N. Wu, +5 authors Jin Li
  • Chemistry, Medicine
  • Journal of cellular biochemistry
  • 2006
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Antiarrhythmic action of rilmenidine on adrenaline‐induced arrhythmia via central imidazoline receptors in halothane‐anaesthetized dogs
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Role of Pertussis Toxin-sensitive G-Proteins in the Analgesic and Anesthetic Actions of alpha sub 2 -Adrenergic Agonists in the Rat
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It is concluded that alpha 2-adrenergic and imidazole receptors are functionally distinct and linked to different signal transduction mechanisms; the classical G-protein coupled soluble second messenger systems are not coupled to imidrazole receptors; clonidine may increase cGMP by a non-receptor-mediated intracellular action; and iminidazol receptors may regulate intrACEllular calcium levels through an ion regulating system that may be different from calcium channels. Expand
[3H]‐idazoxan binding to rabbit cerebral cortex recognises multiple imidazoline I2‐type receptors: pharmacological characterization and relationship to monoamine oxidase
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