The involvement of pertussis toxin‐sensitive G proteins in the post receptor mechanism of central I1‐imidazoline receptors

@article{Takada1997TheIO,
  title={The involvement of pertussis toxin‐sensitive G proteins in the post receptor mechanism of central I1‐imidazoline receptors},
  author={K. Takada and Y. Hayashi and T. Kamibayashi and T. Mammoto and A. Yamatodani and S. Kitamura and I. Yoshiya},
  journal={British Journal of Pharmacology},
  year={1997},
  volume={120}
}
To elucidate the possible involvement of pertussis toxin (PTX)‐sensitive G proteins in the post receptor mechanism of α2‐adrenoceptors and imidazoline receptors, we examined the effect of pretreatment of the central nervous system with PTX on the antidysrhythmic effect of dexmedetomidine, a selective α2‐adrenoceptor agonist, and rilmenidine, a selective I1‐imidazoline receptor agonist on halothane‐adrenaline dysrhythmias in rats. Dexmedetomidine (0, 1.0, 2.0, 5.0 μg kg−1 min−1, i.v.) and… Expand
The Effect of Imidazoline Receptors and α2‐adrenoceptors on the Anesthetic Requirement (MAC) for Halothane in Rats
TLDR
The present data indicate that the anesthetic sparing action of dexmedetomidine is most likely mediated through alpha2 ‐adrenoceptors, and the stimulation of imidazoline receptors exerts little effect on theAnesthetic requirement for halothane. Expand
Involvement of phosphatidylcholine‐selective phospholipase C in activation of mitogen‐activated protein kinase pathways in imidazoline receptor antisera‐selected protein
  • Fei Li, N. Wu, +5 authors Jin Li
  • Chemistry, Medicine
  • Journal of cellular biochemistry
  • 2006
TLDR
The results suggest that the signaling pathway of IRAS in response to I1R agonists coupled with the activation of PC‐PLC and its downstream signal transduction molecule, ERK, similar to those in the signaling pathways of native I 1R, providing some new evidence for the relationship between I1r and IRAS. Expand
Identification of the Central Imidazoline Receptor Subtype Involved in Modulation of Halothane-Epinephrine Arrhythmias in Rats
TLDR
It is concluded that central I1, but not I2, receptors play an important role in inhibition of halothane-epinephrine arrhythmia. Expand
Peripheral and Central Imidazoline Receptor‐Mediated Natriuresis in the Rat a
TLDR
In SH rats, the site(s), and/or receptor(s) responsible for blood pressure lowering were altered and those for increasing sodium excretion appear to be inactive and the significance of the findings in long-term regulation of blood pressure remain to be determined. Expand
Imidazoline Receptor System: The Past, the Present, and the Future
TLDR
Recent progress on drug discovery targeting imidazoline receptors (I1 and I2) demonstrates the exciting potential of these compounds to elicit neuroprotection and to treat various disorders such as hypertension, metabolic syndrome, and chronic pain. Expand
Presynaptic I1-Imidazoline Receptors Reduce GABAergic Synaptic Transmission in Striatal Medium Spiny Neurons
TLDR
The activation of presynaptic I1-imidazoline receptors decreases GABA-mediated inhibition of medium spiny neurons in the striatum, in which NEM-sensitive proteins such as Gi/o-type G-proteins play an essential role. Expand
The antiarrhythmic effect of centrally administered rilmenidine involves muscarinic receptors, protein kinase C and mitochondrial signalling pathways
TLDR
The role of muscarinic receptors, protein kinase C, ATP‐sensitive potassium channels (KATP) and the mitochondrial permeability transition pore (MPTP) in the antiarrhythmic effect of rilmenidine, an imidazoline receptor agonist is examined. Expand
Allosteric modulation of semicarbazide‐sensitive amine oxidase activities in vitro by imidazoline receptor ligands
TLDR
Results reveal an ability of imidazoline ligands to modulate BPAO kinetics allosterically and the derived mechanism may have functional significance with respect to modulation of MAO by I2BS ligands. Expand
Naphazoline-induced Suppression of Aqueous Humor Pressure and Flow: Involvement of Central and Peripheral α2/I1Receptors
Abstract The objective of this study was to examine the ocular hydrodynamic effects of topically and centrally administered naphazoline, alone and following pretreatment with pertussis toxin (PTX)Expand
Imidazoline Receptors and Human Brain Disorders a
ABSTRACT: Major depression, opioid addiction, neurodegenerative diseases, and glial tumors are associated with disturbances of imidazoline receptors (IR) in the human brain. In depression, the levelExpand
...
1
2
...

References

SHOWING 1-10 OF 56 REFERENCES
Antiarrhythmic action of rilmenidine on adrenaline‐induced arrhythmia via central imidazoline receptors in halothane‐anaesthetized dogs
TLDR
It is suggested that the antiarrhythmic action of rilmenidine is due to the activation of central imidazoline receptors and that vagal tone is critical for this action. Expand
Role of Pertussis Toxin-sensitive G-Proteins in the Analgesic and Anesthetic Actions of alpha sub 2 -Adrenergic Agonists in the Rat
TLDR
To address this question, the effects of pretreatment with PTX administered intracerebroventricularly, intrathecally, or a combination of the two were examined, and the anesthetic-sparing and analgesic effects of a systemically administered alpha2 agonist, dexmedetomidine, were examined. Expand
Role of Imidazoline‐preferring Receptors in the Genesis of Epinephrine‐induced Arrhythmias in Halothane‐anesthetized Dogs
BackgroundDrugs with a central α2-adrenergic action can increase the threshold for halothane-eplnephrine-lnduced arrhythmias. Recently, imidazoline-preferrlng receptors were shown to play aExpand
Further Characterization of the Guinea Pig Cerebral Cortex Idazoxan Receptor: Solubilization, Distinction from the Imidazole Site, and Demonstration of Cirazoline as an Idazoxan Receptor‐Selective Drug
TLDR
It is suggested that idazoxan receptors might be involved in the control of prolactin release from the pituitary and shows grossly different binding properties for histamine, cimetidine, and imidazole‐4‐acetic acid compared to what has been described for the nonadrenergic imidAZole site labeled by p‐[3H]aminoclonidine. Expand
Evidence for the involvement of imidazoline receptors in the central hypotensive effect of rilmenidine in the rabbit
TLDR
Rilmenidine exhibited in the rabbit a central hypotensive effect which originated in the same area as where clonidine acts, and specific imidazoline‐preferring receptors appear to be involved in this hypotensiveEffect. Expand
Pertussis toxin and 4-aminopyridine differentially affect the hypnotic-anesthetic action of dexmedetomidine and pentobarbital.
TLDR
Results suggest that the receptor-effector mechanism for the hypnotic-anesthetic action of dexmedetomidine involves an inhibitory G-protein and increased conductance through a potassium channel. Expand
An imidazoline-specific mechanism for the hypotensive effect of clonidine: a study with yohimbine and idazoxan.
TLDR
The hypothesis that the hypotensive action of imidazoline is due to an interaction of these substances with imidrazoline-preferring receptors in the ventrolateral medulla oblongata whereas its sedative effect is related to an action on alpha-2 adrenoceptors is confirmed. Expand
EVIDENCE FOR MEDETOMIDINE AS A SELECTIVE AND POTENT AGONIST α2‐ADRENORECEPTORS
The activity on alpha-adrenoreceptors of medetomidine ((+/-)-4-(alpha,2,3-trimethylbenzyl)imidazole), an alpha-methyl derivative of detomidine, has been characterized in vivo and in vitro usingExpand
Effects of clonidine and other imidazole-receptor binding agents on second messenger systems and calcium influx in bovine adrenal chromaffin cells.
TLDR
It is concluded that alpha 2-adrenergic and imidazole receptors are functionally distinct and linked to different signal transduction mechanisms; the classical G-protein coupled soluble second messenger systems are not coupled to imidrazole receptors; clonidine may increase cGMP by a non-receptor-mediated intracellular action; and iminidazol receptors may regulate intrACEllular calcium levels through an ion regulating system that may be different from calcium channels. Expand
[3H]‐idazoxan binding to rabbit cerebral cortex recognises multiple imidazoline I2‐type receptors: pharmacological characterization and relationship to monoamine oxidase
TLDR
Competition experiments demonstrated that the [3H]‐idazoxan recognition site was insensitive to the catecholamines, adrenaline and noradrenaline and possessed a low affinity for the α2‐ and α1‐adrenoceptor antagonists, rauwolscine, yohimbine and prazosin, suggesting that the site was not an adrenoceptor. Expand
...
1
2
3
4
5
...