The involvement of nitric oxide in the enhanced expression of mu-opioid receptors during intestinal inflammation in mice.

@article{Pol2005TheIO,
  title={The involvement of nitric oxide in the enhanced expression of mu-opioid receptors during intestinal inflammation in mice.},
  author={Olga Pol and Masayuki Sasaki and Natalia Jim{\'e}nez and Valina L. Dawson and Ted M. Dawson and Margarita Mar{\'i}a Puig},
  journal={British journal of pharmacology},
  year={2005},
  volume={145 6},
  pages={
          758-66
        }
}
Intestinal inflammation enhances the potency of mu-opioid receptor (MOR) agonists inhibiting gastrointestinal transit and increases the expression of MOR in mice intestine. The precise mechanisms implicated in the increased expression of MOR during intestinal inflammation are not known. The aim of the study is to evaluate if nitric oxide released during intestinal inflammation could modulate MOR gene expression and affect gastrointestinal transit. Intestinal inflammation was induced by the… CONTINUE READING

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