The involvement of glutamate in the pathophysiology of depression.


In spite of more than 40 years of thorough studies, conventional antidepressants still have many limitations that hinder the effective treatment of depression. It seems that a breakthrough in the therapy of depression will require going beyond a monoamine-based theory of depression. Converging lines of evidence indicate that the glutamatergic system might be a promising target for a novel antidepressant therapy. Both ionotropic glutamate receptor ligands (functional NMDA receptor antagonists and AMPA receptor potentiators) and compounds acting at metabotropic glutamate receptors (mGluRs; group I mGluR antagonists, group II antagonists and group III agonists) produce antidepressant-like activity in several preclinical and some clinical studies. In this review, current knowledge and crucial hypotheses concerning the role of glutamate in the pathophysiology of depression are discussed.

Citations per Year

482 Citations

Semantic Scholar estimates that this publication has 482 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Palucha2005TheIO, title={The involvement of glutamate in the pathophysiology of depression.}, author={Agnieszka Palucha and Andrzej Pilc}, journal={Drug news & perspectives}, year={2005}, volume={18 4}, pages={262-8} }