The involvement of free radicals in the mechanisms of monooxygenases.

  • R. E. White
  • Published 1991 in Pharmacology & therapeutics

Abstract

The occurrence of free radicals in the mechanisms of monooxygenases reflects the chemistry of dioxygen and the inertness of typical substrates. Thus, oxidation of such substrates requires attack by reduced dioxygen-derived free radicals. Consequently, a molecule of NAD(P)H must be invested for each substrate molecule oxidized. Furthermore, since free… (More)

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