The involvement of dopamine in the modulation of sleep and waking.

@article{Monti2007TheIO,
  title={The involvement of dopamine in the modulation of sleep and waking.},
  author={Jaime M. Monti and Daniela Monti},
  journal={Sleep medicine reviews},
  year={2007},
  volume={11 2},
  pages={
          113-33
        }
}
The roles of dopamine and serotonin, and of their receptors, in regulating sleep and waking.
Dopamine and Sleep
TLDR
The dopamine (DA)-ergic neurons are primarily localized in the substantia nigra and ventral tegmental area of the brainstem and may have an indirect modulatory role, which however needs confirmation.
The Effects of Melanin-Concentrating Hormone on Neurotransmitter Systems Involved in the Generation and Maintenance of Wakefulness
TLDR
The REM sleep-inducing and sleep-facilitating effect of MCH is at least partly related to the deactivation of monoaminergic, glutamatergic, and cholinergic (W-on) neurons.
The neurobiology of the substantia nigra pars compacta: from motor to sleep regulation.
TLDR
It is suggested that the dopaminergic system is implicated in the physiology of sleep, with particular regard to the influence of the SNpc neurons.
Phylo- and Ontogenetic Establishment of Dopamine Regulation of the Sleep–Waking Cycle in Vertebrates
TLDR
The question of the formation of the regulatory role of the dopaminergic system in the sleep–waking cycle during phylo- and ontogenesis, when dopamine shows a transition from predominantly diencephalic neurosecretory influences to predominantly telencephalic neurotransmitter influences is addressed.
Functional Interactions Between MCHergic and Dopaminergic Neurons: Role in the Control of Wakefulness and Sleep
TLDR
Indirect evidence strongly suggests that functional interactions between the MCHergic and DAergic systems play an important role in the control of behavioral states and in the regulation of different aspects of REM sleep.
Dopaminergic neurons expressing Fos during waking and paradoxical sleep in the rat
Dopamine in REM Sleep Regulation
TLDR
Relevant literatures suggest that the DA-ergic neurons may have an indirect modulatory role, which however needs confirmation.
Role of Orexin on Sleep: Interactions with Other Neurotransmitter Systems
TLDR
It is hypothesized that the interactions of these opposite but complementary hypothalamic systems are critical for the generation of either wakefulness or sleep.
...
...

References

SHOWING 1-10 OF 192 REFERENCES
Hypocretin/Orexin Selectively Increases Dopamine Efflux within the Prefrontal Cortex: Involvement of the Ventral Tegmental Area
TLDR
The current observations predict a prominent modulatory influence of HCRT on PFC-dependent cognitive and affective processes that results, in part, from actions within the VTA.
Role of the subthalamic nucleus in the regulation of nigral dopamine neuron activity
TLDR
The STN appears to exert a dual action on SN DA cells: initial inhibition possibly mediated through STN excitation of the inhibitory SN ZR projections to DA cells, and a facilitation of burst firing which may be a direct effect of excitatory STN afferents.
Activation of the mesocorticolimbic dopaminergic system by stimulation of muscarinic cholinergic receptors in the ventral tegmental area
TLDR
These data demonstrate that VTA dopamine cells possess functional muscarinic receptors whose activation stimulates the release of dopamine in the VTA, NAC and FC and suggest that mus carinic receptors may modulate the synaptic release of serotonin in theVTA.
Excitation of Ventral Tegmental Area Dopaminergic and Nondopaminergic Neurons by Orexins/Hypocretins
TLDR
Dysfunction of the orexin modulation of VTA neurons may be important in triggering attacks of cataplexy in narcolepsy, in which the Orexin system is disrupted.
Serotonin-dopamine interaction in the rat ventral tegmental area: an electrophysiological study in vivo.
TLDR
Electrophysiological techniques were used to study the effects of various serotonin (5-HT) agonists and antagonists on the activity of dopamine (DA) neurons in the ventral tegmental area of rats and the effect of mCPP was more pronounced compared to that of TFMPP (maximal inhibition, 25%).
Ventral tegmental area: site through which dopamine D2‐receptor agonists evoke behavioural and electrocortical sleep in rats
TLDR
Evidence is provided suggesting that stimulation of dopamine D2‐receptors located at the cell body level and/or the dendrites of dopaminergic neurones in the VTA may represent the mechanism through which apomorphine or (+)−3PPP exert their soporific effects in rats.
Differential effects of dopamine D-1 and D-2 receptor antagonist antipsychotics on sleep-wake patterns in the rat.
TLDR
Concomitant enhancement of both total sleep and REM appears to be a peculiar feature which clearly distinguishes DA D-1 antagonists from the other DA receptor blockers.
Preferential modulation of mesolimbic vs. nigrostriatal dopaminergic function by serotonin2C/2B receptor agonists: a combined in vivo electrophysiological and microdialysis study
TLDR
Data indicate that mCPP and MK 212 selectively inhibit mesolimbic dopaminergic function by acting on 5‐HT2C receptors, and might be useful in clinical conditions where it is necessary to reduce the meslimbic dopamine activity without affecting the nigrostriatal function.
...
...