The involvement of dehydroepiandrosterone (DHEA) and its sulfate ester (DHEAS) in blocking the therapeutic effect of electroconvulsive shocks in an animal model of depression.

@article{Maayan2005TheIO,
  title={The involvement of dehydroepiandrosterone (DHEA) and its sulfate ester (DHEAS) in blocking the therapeutic effect of electroconvulsive shocks in an animal model of depression.},
  author={Rachel Maayan and Oren Morad and Pnina Dorfman and David H. Overstreet and Abraham Weizman and Gal Yadid},
  journal={European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology},
  year={2005},
  volume={15 3},
  pages={253-62}
}
Depressed patients with resistance to electroconvulsive treatment (ECT) had high basal serum levels of dehydroepiandrosterone (DHEA) sulfate (DHEAS). To clarify the role of DHEA/S in the ECT resistance, Flinder Sensitive Line (FSL) rats, which are a genetic animal model of depression, were injected i.p. with 2 mg/kg DHEA daily for 13 days to overload their serum and brain DHEA/S levels. Thereafter, rats were exposed to electroconvulsive shock (ECS), which is analogue to ECT in humans. Both ECS… CONTINUE READING
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