The involvement of cell cycle events in the pathogenesis of Alzheimer's disease

  title={The involvement of cell cycle events in the pathogenesis of Alzheimer's disease},
  author={Karl Herrup},
  booktitle={Alzheimer's Research & Therapy},
Most neurons undergo their last cell division within the first 1 to 2% of the lifespan of an organism. This has been interpreted to mean that adult neurons are permanently postmitotic, but Alzheimer's disease (AD) is an example of a late-onset neurodegenerative disease that challenges this concept. In AD, neurons in populations at risk for death reactivate their cell cycle and replicate their genome - but rather than complete the cycle with mitosis and cytokinesis, the neurons die. While… CONTINUE READING
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Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2003

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