The involvement of calpain-independent proteolysis of the tumor suppressor NF2 (merlin) in schwannomas and meningiomas

@article{Kimura1998TheIO,
  title={The involvement of calpain-independent proteolysis of the tumor suppressor NF2 (merlin) in schwannomas and meningiomas},
  author={Yoriyoshi Kimura and Hisashi Koga and Norie Araki and Norifumi Mugita and Naoyuki Fujita and Hideo Takeshima and Tohru Nishi and Tetsumori Yamashima and Takaomi C Saido and Toshiki Yamasaki and Kouzo Moritake and Hideyuki Saya and Mitsuyoshi Nakao},
  journal={Nature Medicine},
  year={1998},
  volume={4},
  pages={915-922}
}
Neurofibromatosis type 2 (NF2) protein, also known as merlin or schwannomin, is a tumor suppressor, and NF2 is mutated in most schwannomas and meningiomas. Although these tumors are dependent on NF2, some lack detectable NF2 mutations, which indicates that alternative mechanisms exist for inactivating merlin. Here, we demonstrate cleavage of merlin by the ubiquitous protease calpain and considerable activation of the calpain system resulting in the loss of merlin expression in these tumors… CONTINUE READING
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