The involvement of autotaxin in renal interstitial fibrosis through regulation of fibroblast functions and induction of vascular leakage

@inproceedings{Sakai2019TheIO,
  title={The involvement of autotaxin in renal interstitial fibrosis through regulation of fibroblast functions and induction of vascular leakage},
  author={Norihiko Sakai and Gretchen Bain and Kengo Furuichi and Yasunori Iwata and Miki Nakamura and Akinori Hara and Shinji Kitajima and Akihiro Sagara and Taito Miyake and Tadashi Toyama and Koichi Sato and Shiori Nakagawa and Miho Shimizu and Shuichi Kaneko and Takashi Wada},
  booktitle={Scientific Reports},
  year={2019}
}
The accumulation of fibroblasts is a critical step in the development of fibrosis, and lysophosphatidic acid (LPA) promotes fibrosis by regulating multiple fibroblast functions. Autotaxin (ATX) is a key LPA-producing enzyme, and we hypothesized that ATX contributes to the development of renal interstitial fibrosis through LPA-mediated effects on fibroblast functions. In a mouse model of renal interstitial fibrosis induced by unilateral ureteral obstruction (UUO), the levels of renal ATX protein… CONTINUE READING
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