The involvement of RNA in ribosome function

@article{Moore2002TheIO,
  title={The involvement of RNA in ribosome function},
  author={Peter B Moore and Thomas A. Steitz},
  journal={Nature},
  year={2002},
  volume={418},
  pages={229-235}
}
The ribosome is a particle made of RNA and protein that is found in abundance in all cells that are actively making protein. It catalyses the messenger RNA-directed synthesis of proteins. Recent structural work has demonstrated a profound involvement of the ribosome's RNA component in all aspects of its function, supporting the hypothesis that proteins were added to the ribosome late in its evolution. 

5 S rRNA: structure and interactions.

This paper summarizes recently published data on the structure and function of 5 S rRNA and its interactions in complexes with proteins, within and outside the ribosome.

The ribosome and the mechanism of protein synthesis

Cryo-electron microscopy is starting to contribute toward the understanding of the ribosome's function, by portraying its conformational changes and binding interactions with the cofactors and tRNA.

Evolution and assembly of the ribosome

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Structural Insight Into Functional Aspects of Ribosomal RNA Targeting

  • A. Yonath
  • Biology, Chemistry
    Chembiochem : a European journal of chemical biology
  • 2003
Recent advances in studies aimed at the understanding of the molecular mechanisms that are triggered, accomplished, or assisted by rRNA interactions are highlighted.

The structural basis of large ribosomal subunit function.

The work reviewed proves beyond doubt that the ribosome is an RNA enzyme, as had long been surmised on the basis of less conclusive evidence.

Ribosome, High Resolution Structure and Function

The structures show unequivocally that mainly ribosomal RNA is present in the peptidyl transferase center as well as in the decoding center, indicating that it is in fact ribosome RNA that is responsible for all aspects of peptide synthesis.

5.5 Å Structure of the Eukaryotic Ribosome

Cryo-electron microscopy and single-particle reconstruction provide insights into the structure, function and evolution of the eukaryotic translational apparatus with near-complete atomic models of the 80S ribosome.

Antibiotics and the ribosome

The recent progress, problems and new directions of research of ribosome‐targeting antibiotics are discussed in this review.
...

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