The involvement of NK cells in ankylosing spondylitis.

  title={The involvement of NK cells in ankylosing spondylitis.},
  author={Niva Azuz-Lieberman and Gal Markel and Sa'ar Mizrahi and Roi Gazit and Jacob Hanna and Hagit Achdout and Raizy Gruda and Gil Katz and Tal I. Arnon and Shosh Battat and Ehud Zamir and Muhammed Adawi and Reuven Mader and Ofer Mandelboim},
  journal={International immunology},
  volume={17 7},
A role for NK cells in the regulation of autoimmunity has been demonstrated. Since there is a strong association between Ankylosing Spondylitis (AS) and HLA-B27, which is specifically recognized by the NK-inhibitory receptor KIR3DL1, this study evaluated the potential involvement of NK cells in AS. We studied 19 AS patients and 22 healthy volunteer donors and assessed the percentage, activity and receptor expression of peripheral blood NK cells. We also evaluated candidate-inflammatory… CONTINUE READING


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