The involvement of M2 macrophage polarization inhibition in fenretinide-mediated chemopreventive effects on colon cancer.

@article{Dong2017TheIO,
  title={The involvement of M2 macrophage polarization inhibition in fenretinide-mediated chemopreventive effects on colon cancer.},
  author={Rong Dong and Yanling Gong and Wen Meng and Meng Yuan and Hong Zhu and Meidan Ying and Qiaojun He and Ji Rong Cao and Bo Yang},
  journal={Cancer letters},
  year={2017},
  volume={388},
  pages={43-53}
}
Clinical studies have shown that fenretinide (4-HPR) is an attractive chemopreventive agent for cancer treatment. However, to date, few studies have demonstrated the mechanism of the preventive effect of 4-HPR. In our current study, we revealed that 4-HPR could significantly suppress IL-4/IL-13 induced M2-like polarization of macrophages, which was demonstrated by the reduced expression of M2 surface markers, the down-regulation of M2 marker genes, and the inhibition of M2-like macrophages… CONTINUE READING
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