The involvement of Fas-Fas ligand pathway in fibrosing lung diseases.

@article{Kuwano1999TheIO,
  title={The involvement of Fas-Fas ligand pathway in fibrosing lung diseases.},
  author={Kazuyoshi Kuwano and Hiroyuki Miyazaki and Naoki Hagimoto and Masanobu Kawasaki and Masaki J. Fujita and Ritsuko Kunitake and Yoshikatsu Kaneko and Nobuyuki Hara},
  journal={American journal of respiratory cell and molecular biology},
  year={1999},
  volume={20 1},
  pages={53-60}
}
Pulmonary fibrosis begins with alveolitis, which progresses to destruction of lung tissue and excess collagen deposition. This process could be the result of DNA damage and a form of apoptosis. Therefore, we hypothesized that Fas ligand (FasL), which induces apoptosis in cells expressing Fas antigen (Fas), is associated with pulmonary fibrosis. We examined… CONTINUE READING