The involvement of Eph-Ephrin signaling in tissue separation and convergence during Xenopus gastrulation movements.

@article{Park2011TheIO,
  title={The involvement of Eph-Ephrin signaling in tissue separation and convergence during Xenopus gastrulation movements.},
  author={Edmond Changkyun Park and Gun-Sik Cho and Gun-Hwa Kim and S C Choi and Jin-Kwan Han},
  journal={Developmental biology},
  year={2011},
  volume={350 2},
  pages={441-50}
}
In Xenopus gastrulation, the involuting mesodermal and non-involuting ectodermal cells remain separated from each other, undergoing convergent extension. Here, we show that Eph-ephrin signaling is crucial for the tissue separation and convergence during gastrulation. The loss of EphA4 function results in aberrant gastrulation movements, which are due to selective inhibition of tissue constriction and separation. At the cellular levels, knockdown of EphA4 impairs polarization and migratory… CONTINUE READING