The involvement of DNA and histone methylation in the repression of IL-1β-induced MCP-1 production by hypoxia.

@article{Aoi2011TheIO,
  title={The involvement of DNA and histone methylation in the repression of IL-1β-induced MCP-1 production by hypoxia.},
  author={Yoko Aoi and Ken-ichi Nakahama and Ikuo Morita and Olga S. Safronova},
  journal={Biochemical and biophysical research communications},
  year={2011},
  volume={414 1},
  pages={
          252-8
        }
}
  • Yoko Aoi, Ken-ichi Nakahama, +1 author Olga S. Safronova
  • Published in
    Biochemical and biophysical…
    2011
  • Biology, Medicine
  • Hypoxia is a microenvironmental pathophysiologic factor commonly associated with tumors and tissue inflammation. We previously reported that hypoxia repressed IL-1β-induced monocyte chemoattractant protein-1 (MCP-1) expression. The purpose of this study was to investigate the mechanisms involved in the repression of MCP-1 expression under hypoxia. Treatment of HeLa cells with 5-aza-dC, an inhibitor of DNA methylation, abolished the repression of IL-1β-induced MCP-1 expression by hypoxia. A… CONTINUE READING

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