The involvement of AMP-activated protein kinases in the anti-inflammatory effect of nicotine in vivo and in vitro.

@article{Cheng2007TheIO,
  title={The involvement of AMP-activated protein kinases in the anti-inflammatory effect of nicotine in vivo and in vitro.},
  author={Pao-Yun Cheng and Yen-Mei Lee and Kwok-Keung Law and Chia-Wei Lin and Mao-Hsiung Yen},
  journal={Biochemical pharmacology},
  year={2007},
  volume={74 12},
  pages={
          1758-65
        }
}
AMP-activated protein kinase (AMPK) is the downstream component of a kinase cascade that plays a pivotal role in energy homeostasis. AMPK has recently emerged as an attractive and novel target for inflammatory disorders. Thus, the aim of this study was to assess the role of AMPKalpha in the anti-inflammatory effect of nicotine in carrageenan-induced rat paw edema model and to evaluate the mechanism of nicotine-induced AMPKalpha phosphorylation in RAW 264.7 cells. The results indicate that… CONTINUE READING

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