The investigational new drug XK469 induces G(2)-M cell cycle arrest by p53-dependent and -independent pathways.

  title={The investigational new drug XK469 induces G(2)-M cell cycle arrest by p53-dependent and -independent pathways.},
  author={Zhijie Ding and Ralph E. Parchment and Patricia M. LoRusso and Jian Y. Zhou and Janke Li and Theodore Steven Lawrence and Yuan Sun and Gen Sheng Wu},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={7 11},
PURPOSE XK469 (2-[4-(7-chloro-2-quinoxalinyloxy) phenoxy]propionic acid), a synthetic quinoxaline phenoxypropionic acid derivative, has broad activity against murine tumors and is entering Phase I clinical development as a topoisomerase IIbeta inhibitor. This study investigated the underlying molecular mechanism of XK469's effects on the cell cycle. EXPERIMENTAL DESIGN Growth inhibition, cell cycle arrest, induction of p53 and p21 mRNA and protein, and cdc2 phosphorylation and kinase activity… CONTINUE READING


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