The investigation into CYP2E1 in relation to the level of response to alcohol through a combination of linkage and association analysis.

@article{Webb2011TheII,
  title={The investigation into CYP2E1 in relation to the level of response to alcohol through a combination of linkage and association analysis.},
  author={Amy E. Webb and Penelope A. Lind and Jelger A Kalmijn and Heidi S. Feiler and Tom L Smith and Marc A Schuckit and K. Wilhelmsen},
  journal={Alcoholism, clinical and experimental research},
  year={2011},
  volume={35 1},
  pages={10-8}
}
BACKGROUND A low level of response to alcohol during an individual's early experience with alcohol is associated with an increase risk of alcoholism. A family-based genome-wide linkage analysis using sibling pairs that underwent an alcohol challenge where the level of response to alcohol was measured with the Subjective High Assessment Scale (SHAS) implicated the 10q terminal (10qter) region. CYP2E1, a gene known for its involvement with ethanol metabolism, maps to this region. METHODS… CONTINUE READING
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