• Corpus ID: 28362755

The inverse relationship between active components present in cruciferous vegetables and in vitro and in vivo carcinogenesis has been associated with lower risk of lung and colorectal cancer in some epidemiological studies

@inproceedings{Moreno2009TheIR,
  title={The inverse relationship between active components present in cruciferous vegetables and in vitro and in vivo carcinogenesis has been associated with lower risk of lung and colorectal cancer in some epidemiological studies},
  author={Diego A. Moreno and Carmen L{\'o}pez-Berenguer and Micaela Carvajal and Cristina Garc{\'i}a-Viguera},
  year={2009}
}
Broccoli (Brassica oleracea L. var. italica) is a well recognized health-promoting vegetable due to its high beneficial compound content. Numerous epidemiological studies indicate that Brassicas, in general, and broccoli in particular, protect humans against some diseases since they are rich sources of glucosinolates as well as possessing a high content on flavonoids, vitamins and mineral nutrients. Glucosinolates are characteristic Brassicaceae compounds that, when the tissue is damaged, are… 

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TLDR
The evidence of efficacy is weak for carotenoids and polyphenols; the evidence is stronger for glucosinolates and lycopene, but production of enriched foods still is premature; and there is unacceptable variability in the amount and chemical form of these compounds in plants.
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TLDR
This work has attempted to summarize experimental carcinogenesis studies as well as clinical trials and studies on the mechanism of action of selective chemopreventive agents isolated and identified within these natural products.
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TLDR
In experimental animals cruciferous vegetables have been shown to inhibit chemically-induced colon cancer and this disparity may reflect a lack of sensitivity of such studies.
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TLDR
Brassica vegetables are protective against various classes of DNA-reactive carcinogens, can reduce chemically induced tumor formation, attenuate the effects of polycyclic aromatic hydrocarbons and nitrosoamines and have a protective effect against heterocyclic amines.
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TLDR
High combination dietary doses of I3C and crambene demonstrated enhanced protection from AFB(1), and low combination doses, as might be realistically in the diet, were not effective.
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TLDR
The anticarcinogenic bioactivities of glucosinolate hydrolysis products, the mineral selenium derived from crucifers, and the mechanisms by which they protect against cancer are described.
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The chemoprotective effect of cruciferous vegetables is due to their high glucosinolate content and the capacity of glucosinolate metabolites, such as isothiocyanates (ITC) and indoles, to modulate
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