The invasion routes of neurovirulent A/Hong Kong/483/97 (H5N1) influenza virus into the central nervous system after respiratory infection in mice

@article{Park2001TheIR,
  title={The invasion routes of neurovirulent A/Hong Kong/483/97 (H5N1) influenza virus into the central nervous system after respiratory infection in mice},
  author={C. H. Park and M. Ishinaka and Ayato Takada and Hiroshi Kida and Takashi Kimura and Kenji Ochiai and Takashi Umemura},
  journal={Archives of Virology},
  year={2001},
  volume={147},
  pages={1425-1436}
}
A/Hong Kong/483/97 (H5N1) influenza virus (HK483) isolated from the third patient during the outbreak of chicken and human influenza in Hong Kong in 1997 was shown to be neurovirulent in mice. HK483 was inoculated intranasally to mice, and the invasion routes of the virus in the central nervous system (CNS) were investigated by immunohistochemical and in situ hybridization. The pathological changes consisted of bronchopneumonia, ganglionitis, and nonpurulent encephalomyelitis of the brain stem… CONTINUE READING
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