The invasion protein InIB from Listeria monocytogenes activates PLC-gamma1 downstream from PI 3-kinase.

@article{Bierne2000TheIP,
  title={The invasion protein InIB from Listeria monocytogenes activates PLC-gamma1 downstream from PI 3-kinase.},
  author={H{\'e}l{\`e}ne Bierne and Shaynoor Dramsi and M P Gratacap and Clotilde Randriamampita and Graham F Carpenter and Bernard Payrastre and Pascale Cossart},
  journal={Cellular microbiology},
  year={2000},
  volume={2 6},
  pages={465-76}
}
Entry of the bacterial pathogen Listeria monocytogenes into non-phagocytic mammalian cells is mainly mediated by the InlB protein. Here we show that in the human epithelial cell line HEp-2, the invasion protein InlB activates sequentially a p85beta-p110 class I(A) PI 3-kinase and the phospholipase C-gamma1 (PLC-gamma1) without detectable tyrosine phosphorylation of PLC-gamma1. Purified InlB stimulates association of PLC-gamma1 with one or more tyrosine-phosphorylated proteins, followed by a… CONTINUE READING

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