The invasion inhibitor sarasinoside A1 reverses mesenchymal tumor transformation in an E-cadherin-independent manner.

@article{Austin2013TheII,
  title={The invasion inhibitor sarasinoside A1 reverses mesenchymal tumor transformation in an E-cadherin-independent manner.},
  author={Pamela Austin and Spencer A. Freeman and Christopher A Gray and Michael R Gold and A Wayne Vogl and Raymond J Andersen and Michel Roberge and Calvin D Roskelley},
  journal={Molecular cancer research : MCR},
  year={2013},
  volume={11 5},
  pages={530-40}
}
During metastatic progression, an aberrant epithelial-to-mesenchymal transformation (EMT) that is most often driven by the loss of the cell-cell adhesion molecule E-cadherin generates noncohesive tumor cells that are highly invasive. We used mesenchymally transformed, E-cadherin-negative MDA-MB-231 breast carcinoma cells in a natural product screen and determined that the triterpenoid saponin sarasinoside A1 inhibited their invasion and the invasion of a number of other tumor cell lines… CONTINUE READING