The introduction of QF-PCR in prenatal diagnosis of fetal aneuploidies: time for reconsideration.

@article{Nicolini2004TheIO,
  title={The introduction of QF-PCR in prenatal diagnosis of fetal aneuploidies: time for reconsideration.},
  author={Umberto Nicolini and Faustina Lalatta and Federica Natacci and Cristina Curcio and Thi Mai Anh Bui},
  journal={Human reproduction update},
  year={2004},
  volume={10 6},
  pages={541-8}
}
Quantitative fluorescent polymerase chain reaction (QF-PCR) has recently entered the field of prenatal diagnosis to overcome the need to culture fetal cells, hence to allow rapid diagnosis of some selected chromosomal anomalies. We reviewed the studies on the accuracy of QF-PCR in detecting chromosomal anomalies at prenatal diagnosis. Overall, 22 504 samples have been analysed. The detection rate of aneuploidies of the selected chromosomes (13, 18 and 21, and X and Y) was 98.6% (95% confidence… CONTINUE READING

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