The intrinsic pathway of coagulation: a target for treating thromboembolic disease?

@article{Gailani2007TheIP,
  title={The intrinsic pathway of coagulation: a target for treating thromboembolic disease?},
  author={David Gailani and Thomas Renn{\'e}},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2007},
  volume={5 6},
  pages={
          1106-12
        }
}
The classic intrinsic pathway of coagulation is triggered by contact activation of the plasma protease factor (F)XII, followed by sequential proteolytic activation of FX1 and FIX. While a key mechanism for initiating coagulation in some clinically useful in vitro assays, the absence of abnormal bleeding associated with congenital FXII deficiency indicates that the intrinsic pathway is not important for normal blood coagulation in vivo. However, recent work with mice lacking FXII or FXI suggest… CONTINUE READING
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