The intrinsic innervation of the lung is derived from neural crest cells as shown by optical projection tomography in Wnt1-Cre;YFP reporter mice.

@article{Freem2010TheII,
  title={The intrinsic innervation of the lung is derived from neural crest cells as shown by optical projection tomography in Wnt1-Cre;YFP reporter mice.},
  author={Lucy J Freem and Sophie Escot and David Tannahill and Noah R. Druckenbrod and Nikhil Thapar and Alan J Burns},
  journal={Journal of anatomy},
  year={2010},
  volume={217 6},
  pages={
          651-64
        }
}
Within the embryonic lung, intrinsic nerve ganglia, which innervate airway smooth muscle, are required for normal lung development and function. We studied the development of neural crest-derived intrinsic neurons within the embryonic mouse lung by crossing Wnt1-Cre mice with R26R-EYFP reporter mice to generate double transgenic mice that express yellow fluorescent protein (YFP) in all neural crest cells (NCCs) and their derivatives. In addition to utilizing conventional immunohistochemistry on… CONTINUE READING
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