The intrinsic cycle length in small pieces isolated from the rabbit sinoatrial node.

@article{Opthof1987TheIC,
  title={The intrinsic cycle length in small pieces isolated from the rabbit sinoatrial node.},
  author={Tobias Opthof and A C Vanginneken and Lennart N. Bouman and Habo J. Jongsma},
  journal={Journal of molecular and cellular cardiology},
  year={1987},
  volume={19 9},
  pages={923-34}
}
In this study we show that small pieces of tissue cut from the intact sinoatrial node beat faster, but with the same regularity as the intact sinoatrial node. The pieces with highest diastolic depolarization rate are not isolated from the primary pacemaker area, but from sites closer to the crista terminalis. In pieces cut from the primary pacemaker area, changes in the action potential configuration are restricted to the action potential duration, whereas in pieces cut from sites closer to the… CONTINUE READING