The intrinsic conformational features of amino acids from a protein coil library and their applications in force field development.

@article{Jiang2013TheIC,
  title={The intrinsic conformational features of amino acids from a protein coil library and their applications in force field development.},
  author={Fan Jiang and Wei Han and Yun-Dong Wu},
  journal={Physical chemistry chemical physics : PCCP},
  year={2013},
  volume={15 10},
  pages={3413-28}
}
The local conformational (φ, ψ, χ) preferences of amino acid residues remain an active research area, which are important for the development of protein force fields. In this perspective article, we first summarize spectroscopic studies of alanine-based short peptides in aqueous solution. While most studies indicate a preference for the P(II) conformation in the unfolded state over α and β conformations, significant variations are also observed. A statistical analysis from various coil… CONTINUE READING

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