The intrinsic antinociceptive effects of oxycodone appear to be κ-opioid receptor mediated

@article{Ross1997TheIA,
  title={The intrinsic antinociceptive effects of oxycodone appear to be κ-opioid receptor mediated},
  author={F. Ross and M. Smith},
  journal={Pain},
  year={1997},
  volume={73},
  pages={151-157}
}
  • F. Ross, M. Smith
  • Published 1997
  • Medicine
  • Pain
  • &NA; Our previous studies in the Sprague–Dawley rat showed that the intrinsic antinociceptive effects of oxycodone are naloxone reversible in a manner analogous to morphine but that in contrast to morphine, oxycodone's antinociceptive effects have a rapid onset of maximum effect (≈5–7 min compared to 30–45 min for morphine), comprise one antinociceptive phase (compared to two phases) and are of relatively short duration (≈90 min compared to ≈180 min). In the present study, administration of a… CONTINUE READING
    180 Citations
    Activation of delta-opioid receptor contributes to the antinociceptive effect of oxycodone in mice.
    • 16
    Characterization of the antinociceptive effect of oxycodone in male and female rats
    • 45
    Involvement of mu1-opioid receptor on oxycodone-induced antinociception in diabetic mice.
    • 30
    Incomplete, asymmetric, and route-dependent cross-tolerance between oxycodone and morphine in the Dark Agouti rat.
    • 47
    • PDF
    Oxycodone: a pharmacological and clinical review
    • 70

    References

    SHOWING 1-10 OF 45 REFERENCES
    The intrinsic antinociceptive effects of oxycodone appear to be kappa-opioid receptor mediated.
    • 100
    The antinociceptive potencies of oxycodone, noroxycodone and morphine after intracerebroventricular administration to rats.
    • 58
    Analgesic effects of intraventricular morphine and enkephalins in nondependent and morphine-dependent rats.
    • 54
    Nor-binaltorphimine, a highly selective kappa-opioid antagonist in analgesic and receptor binding assays.
    • 391
    Antinociceptive effects and central nervous system depression caused by oxycodone and morphine in rats.
    • 76
    • Highly Influential
    Pharmacology of the allodynia in rats evoked by high dose intrathecal morphine.
    • T. Yaksh, G. Harty
    • Chemistry, Medicine
    • The Journal of pharmacology and experimental therapeutics
    • 1988
    • 196
    • Highly Influential
    U-50,488: a selective and structurally novel non-Mu (kappa) opioid agonist.
    • 758
    The influence of pharmacogenetics on opioid analgesia: studies with codeine and oxycodone in the Sprague-Dawley/Dark Agouti rat model.
    • 71
    • Highly Influential
    Morphine-3-Glucuronide — A potent antagonist of morphine analgesia
    • 149