The intrinsic antinociceptive effects of oxycodone appear to be κ-opioid receptor mediated

  title={The intrinsic antinociceptive effects of oxycodone appear to be κ-opioid receptor mediated},
  author={F. Ross and M. Smith},
  • F. Ross, M. Smith
  • Published 1997
  • Medicine
  • Pain
  • &NA; Our previous studies in the Sprague–Dawley rat showed that the intrinsic antinociceptive effects of oxycodone are naloxone reversible in a manner analogous to morphine but that in contrast to morphine, oxycodone's antinociceptive effects have a rapid onset of maximum effect (≈5–7 min compared to 30–45 min for morphine), comprise one antinociceptive phase (compared to two phases) and are of relatively short duration (≈90 min compared to ≈180 min). In the present study, administration of a… CONTINUE READING
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