The intrarenal renin-angiotensin system in hypertension.

  title={The intrarenal renin-angiotensin system in hypertension.},
  author={R. M. Carey},
  journal={Advances in chronic kidney disease},
  volume={22 3},
The renin-angiotensin system (RAS) is a well-studied hormonal cascade controlling fluid and electrolyte balance and blood pressure through systemic actions. The classical RAS includes renin, an enzyme catalyzing the conversion of angiotensinogen to angiotensin (Ang) I, followed by angiotensin-converting enzyme (ACE) cleavage of Ang I to II, and activation of AT1 receptors, which are responsible for all RAS biologic actions. Recent discoveries have transformed the RAS into a far more complex… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 22 extracted citations


Publications referenced by this paper.
Showing 1-10 of 90 references

AT2 receptors: beneficial counter-regulatory role in natriuresis: intrarenal mechanisms and therapeutic potential

SH Padia, RM Carey
Pflugers Arch • 2013

Similar Papers

Loading similar papers…