The intrarenal renin-angiotensin system: from physiology to the pathobiology of hypertension and kidney disease.

@article{Kobori2007TheIR,
  title={The intrarenal renin-angiotensin system: from physiology to the pathobiology of hypertension and kidney disease.},
  author={Hiroyuki Kobori and Masaomi Nangaku and Luis Gabriel Navar and Akira Nishiyama},
  journal={Pharmacological reviews},
  year={2007},
  volume={59 3},
  pages={
          251-87
        }
}
In recent years, the focus of interest on the role of the renin-angiotensin system (RAS) in the pathophysiology of hypertension and organ injury has changed to a major emphasis on the role of the local RAS in specific tissues. In the kidney, all of the RAS components are present and intrarenal angiotensin II (Ang II) is formed by independent multiple mechanisms. Proximal tubular angiotensinogen, collecting duct renin, and tubular angiotensin II type 1 (AT1) receptors are positively augmented by… CONTINUE READING

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