The intrahippocampal administration of the neurosteroid allopregnanolone blocks the audiogenic seizures induced by nicotine.

@article{MartnGarca2005TheIA,
  title={The intrahippocampal administration of the neurosteroid allopregnanolone blocks the audiogenic seizures induced by nicotine.},
  author={Elena Mart{\'i}n-Garc{\'i}a and M G{\'o}mez Pallar{\`e}s},
  journal={Brain research},
  year={2005},
  volume={1062 1-2},
  pages={144-50}
}
Allopregnanolone (AlloP), GABA(A) positive modulator, has efficacy as anticonvulsant. In contrast, nicotine and pregnenolone sulfate (PregS) act as potent convulsants. The present study aims to evaluate whether a promnesic dose of PregS and/or an anxiolytic dose of AlloP administered in the hippocampus can affect the audiogenic seizures induced by nicotine administration. Rats were assigned at random to six groups that received two consecutive intrahippocampal (dorsal CA1) injections once a… CONTINUE READING

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