The intracerebral application of the PPARgamma-ligand pioglitazone confers neuroprotection against focal ischaemia in the rat brain.

@article{Zhao2005TheIA,
  title={The intracerebral application of the PPARgamma-ligand pioglitazone confers neuroprotection against focal ischaemia in the rat brain.},
  author={Yi Zhao and Andreas Patzer and Peter Gohlke and Thomas Herdegen and Juraj Culman},
  journal={The European journal of neuroscience},
  year={2005},
  volume={22 1},
  pages={278-82}
}
The present study addresses the neuroprotective function of intracerebroventricular (i.c.v.) application of pioglitazone, a selective ligand of the peroxisome proliferator-activated receptor gamma (PPARgamma) in the rat brain after ischaemia. Pioglitazone or vehicle were i.c.v. infused via osmotic minipumps over a 5-day period before, and 2 days after transient middle cerebral artery occlusion (MCAO) for 90 min. This i.c.v. application of pioglitazone in the brain significantly reduced the… CONTINUE READING
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