The intracellular pathway for the presentation of vitamin B–related antigens by the antigen-presenting molecule MR1

Abstract

The antigen-presenting molecule MR1 presents vitamin B–related antigens (VitB antigens) to mucosal-associated invariant T (MAIT) cells through an uncharacterized pathway. We show that MR1, unlike other antigen-presenting molecules, does not constitutively present self-ligands. In the steady state it accumulates in a ligand-receptive conformation within the… (More)
DOI: 10.1038/ni.3416

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