• Biology, Medicine
  • Published in Development 1996

The intracellular deletions of Delta and Serrate define dominant negative forms of the Drosophila Notch ligands.

@article{Sun1996TheID,
  title={The intracellular deletions of Delta and Serrate define dominant negative forms of the Drosophila Notch ligands.},
  author={Xiaodong Sun and Spyros Artavanis-Tsakonas},
  journal={Development},
  year={1996},
  volume={122 8},
  pages={
          2465-74
        }
}
We examined the function of the intracellular domains of the two known Drosophila Notch ligands, Delta and Serrate, by expressing wild-type and mutant forms in the developing Drosophila eye under the sevenless promoter. The expression of intracellularly truncated forms of either Delta (sev-DlTM) or Serrate (sev-SerTM) leads to extra photoreceptor phenotypes, similar to the eye phenotypes associated with loss-of-function mutations of either Notch or Delta. Consistent with the notion that the… CONTINUE READING

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