The intracellular 52-kd Ro/SSA autoantigen in keratinocytes is up-regulated by tumor necrosis factor alpha via tumor necrosis factor receptor I.

@article{Gerl2005TheI5,
  title={The intracellular 52-kd Ro/SSA autoantigen in keratinocytes is up-regulated by tumor necrosis factor alpha via tumor necrosis factor receptor I.},
  author={Velia Gerl and Bj{\"o}rn Hostmann and Christa M Johnen and Aderajew Waka and Markus Gerl and Frank Schumann and Rolf Klein and Andreas Radbruch and Falk Hiepe},
  journal={Arthritis and rheumatism},
  year={2005},
  volume={52 2},
  pages={531-8}
}
OBJECTIVE Previous studies have shown that the nuclear Ro/SSA autoantigens involved in photosensitive cutaneous lupus manifestations are regulated by ultraviolet B (UVB) irradiation. UVB exposure triggers the release of tumor necrosis factor alpha (TNFalpha) from keratinocytes in the epidermis and from mast cells in the dermis. The present study aimed to characterize the effect of TNFalpha on messenger RNA (mRNA) and protein expression of the intracellular 52-kd Ro/SSA autoantigen in primary… CONTINUE READING

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