The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice.

@article{Bercik2011TheIM,
  title={The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice.},
  author={Premysl Bercik and Emmanuel Denou and Josh Collins and Wendy Jackson and Jun Lu and Jennifer Jury and Yikang Deng and Patricia A Blennerhassett and Joseph Macri and Kathy D McCoy and Elena F. Verd{\'u} and Stephen M. Collins},
  journal={Gastroenterology},
  year={2011},
  volume={141 2},
  pages={599-609, 609.e1-3}
}
BACKGROUND & AIMS Alterations in the microbial composition of the gastrointestinal tract (dysbiosis) are believed to contribute to inflammatory and functional bowel disorders and psychiatric comorbidities. We examined whether the intestinal microbiota affects behavior and brain biochemistry in mice. METHODS Specific pathogen-free (SPF) BALB/c mice, with or without subdiaphragmatic vagotomy or chemical sympathectomy, or germ-free BALB/c mice received a mixture of nonabsorbable antimicrobials… CONTINUE READING
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