The interstitial nuclei of the human anterior hypothalamus: an investigation of sexual variation in volume and cell size, number and density

  title={The interstitial nuclei of the human anterior hypothalamus: an investigation of sexual variation in volume and cell size, number and density},
  author={William M Byne and Mitchell S. Lasco and Eileen M. Kemether and Akbar Shinwari and Mark A Edgar and Susan Morgello and Liesl B. Jones and Stuart A. Tobet},
  journal={Brain Research},

Galanin neurons in the intermediate nucleus (InM) of the human hypothalamus in relation to sex, age, and gender identity

Organizational and activational hormone effects on the InM are discussed and a sex difference in the younger age group (<45 years of age) is found and an age difference, with a decrease in volume and Gal‐Ir neuron number in males > 45 years is found.

Sex differences in the hypothalamus in the different stages of human life

Sexual Differentiation of the Bed Nucleus of the Stria Terminalis in Humans May Extend into Adulthood

It is found that the sexually dimorphic central subdivision of the bed nucleus of the stria terminalis was larger and contains more neurons in men than in women in adulthood, showing that sexual differentiation of the human brain may extend into the adulthood.

Sexual dimorphism in the bed nucleus of the stria terminalis, medial preoptic area and suprachiasmatic nucleus in male and female tree shrews

These findings are the first to reveal sexual dimorphism in the SCN, BST and MPA of the tree shrew brain, providing neuroanatomical evidence of sexual dimmorphism in these regions related to their roles in sex differences in physiology and behaviour.

The volume of a sexually dimorphic nucleus in the ovine medial preoptic area/anterior hypothalamus varies with sexual partner preference.

Results suggest that naturally occurring variations in sexual partner preferences may be related to differences in brain anatomy and capacity for estrogen synthesis.

The ovine sexually dimorphic nucleus of the medial preoptic area is organized prenatally by testosterone.

Data demonstrate that testosterone acts during a prenatal critical period to organize the development of aromatase-expressing neurons into the male-typical oSDN in sheep.

Sex in the brain . Gender differences in the human hypothalamus and adjacent areas . Relationship to transsexualism , sexual orientation , sex hormone receptors and endocrine status

Women revealed more nuclear ERfJ-ir thann men of a low to intermediat e level, e.g., in the suprachiasmatic, supraoptic, paraventricular, infundibular, and medial mamillary nucleus, which indicate potential sex differences in ERfFJ expression.

A sex difference in the hypothalamic uncinate nucleus: relationship to gender identity.

It is proposed that the sex reversal of the INAH3 in transsexual people is at least partly a marker of an early atypical sexual differentiation of the brain and that the changes in INah3 and the BSTc may belong to a complex network that may structurally and functionally be related to gender identity.



Two sexually dimorphic cell groups in the human brain

A quantitative analysis of the volume of 4 cell groups in the preoptic- anterior hypothalamic area (PO-AHA) and of the supraoptic nucleus (SON) of the human brain was performed in 22 age-matched male

Medial preoptic sexual dimorphisms in the guinea pig. I. An investigation of their hormonal dependence

  • W. ByneR. Bleier
  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1987
It is suggested that androgens continue to exert organizational influences upon the developing brain after cytoarchitectonic patterns have been determined.

Sexually dimorphic regions in the medial preoptic area and the bed nucleus of the stria terminalis of the guinea pig brain: a description and an investigation of their relationship to gonadal steroids in adulthood

Attention to the sex differences in these areas may help elucidate more precisely the neural basis for sexually dimorphic functions, as well as the basic mechanisms underlying sexual differentiation of behavior and the brain.

Cytoarchitectonic sexual dimorphisms of the medial preoptic and anterior hypothalamic areas in guinea pig, rat, hamster, and mouse

There is nearly continuous variation in cellular distribution or packing density as one pro‐ceeds rostrocaudally, as well as variations between females and males at corresponding levels within the sexually dimorphic nuclear complex of the medial preoptic‐anterior hypothalamic area.

Adult testosterone levels influence the morphology of a sexually dimorphic area in the mongolian gerbil brain

This research shows that the medial preoptic area‐anterior hypothalamus of the gerbil contains a sexually dimorphic area (SDA) whose morphology is influenced by adult gonadal steroids, and changes in the gross morphology of the mammalian brain after steroid hormone manipulations in adulthood are reported.

A sexually dimorphic nucleus in the human brain.

A sexually dimorphic cell group is described in the preoptic area of the human hypothalamus, located within an area that is essential for gonadotropin release and sexual behavior in other mammals.