In rats with local chronic carrageenin-induced inflammation of oral soft tissue, the levels of catecholamines and protein were measured in the submaxillary salivary glands, oral mucosa during pilocarpine-induced and background secretions and in saliva during induced secretion. The levels of epinephrine and protein were found to be increased during background secretion in the oral mucosa in chronic inflammation. After stimulation of a secretory cycle in the salivary glands, the contents of epinephrine were increased, but those of protein were decreased. The levels of epinephrine, norepinephrine and proteins were higher in the oral mucosa. It is concluded that chronic oral soft tissue inflammation results in an increase in neurotrophic effects on oral tissues, which contributes to the formation of their protection preventing the generalization of acute inflammation and its transformation to chronic forms.